Sprinkle brisket with meat tenderizer, then cover with both bottles of Liquid Smoke. Refrigerate overnight, covered with foil.
The next day, sprinkle brisket with the dry mixture. Cover tightly with foil and bake for 2 hours at 300° F.
Loosen foil and bake for 5 hours more at 200° F.
Slice brisket very thin across the grain and serve with some of the sauce in the pan.
Serve with your favorite barbecue sauce, if desired.
Servings: 6 to 8